Human AMHR2 activation kit by CRISPRa

CAT#: GA100184

AMHR2 CRISPRa kit - CRISPR gene activation of human anti-Mullerian hormone receptor type 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AMHR2
• Locus ID: 269
• Kit Components:

  GA100184G1, AMHR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100184G2, AMHR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100184G3, AMHR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164690, NM_001164691, NM_020547
• Synonyms: AMHR; MISR2; MISRII; MRII
• Summary: This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]