Human AMPD1 activation kit by CRISPRa

CAT#: GA100185

AMPD1 CRISPRa kit - CRISPR gene activation of human adenosine monophosphate deaminase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AMPD1
• Locus ID: 270
• Kit Components:

  GA100185G1, AMPD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100185G2, AMPD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100185G3, AMPD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000036, NM_001172626
• Synonyms: MAD; MADA; MMDD
• Summary: 'Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]'