Human FE65 (APBB1) activation kit by CRISPRa

CAT#: GA100223

APBB1 CRISPRa kit - CRISPR gene activation of human amyloid beta precursor protein binding family B member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APBB1
• Locus ID: 322
• Kit Components:

  GA100223G1, FE65 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100223G2, FE65 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100223G3, FE65 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164, NM_001257319, NM_001257320, NM_001257321, NM_001257322, NM_001257323, NM_001257324, NM_001257325, NM_001257326, NM_145689, NR_047512
• Synonyms: FE65; MGC:9072; RIR
• Summary: 'The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]'