Human cIAP1 (BIRC2) activation kit by CRISPRa

CAT#: GA100230

BIRC2 CRISPRa kit - CRISPR gene activation of human baculoviral IAP repeat containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BIRC2
• Locus ID: 329
• Kit Components:

  GA100230G1, cIAP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100230G2, cIAP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100230G3, cIAP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166, NM_001256163, NM_001256166
• Synonyms: API1; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; RNF48
• Summary: 'The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]'