Human APLP1 activation kit by CRISPRa

CAT#: GA100234

APLP1 CRISPRa kit - CRISPR gene activation of human amyloid beta precursor like protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APLP1
• Locus ID: 333
• Kit Components:

  GA100234G1, APLP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100234G2, APLP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100234G3, APLP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024807, NM_005166
• Synonyms: APLP
• Summary: 'This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]'