Human APLP2 activation kit by CRISPRa

CAT#: GA100235

APLP2 CRISPRa kit - CRISPR gene activation of human amyloid beta precursor like protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APLP2
• Locus ID: 334
• Kit Components:

  GA100235G1, APLP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100235G2, APLP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100235G3, APLP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142276, NM_001142277, NM_001142278, NM_001243299, NM_001642, NR_024515, NR_024516, NM_001328682, NM_001328684, NM_001328685, NM_001328686
• Synonyms: APLP-2; APPH; APPL2; CDEBP
• Summary: 'This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]'