Human Apolipoprotein CII (APOC2) activation kit by CRISPRa

CAT#: GA100243

APOC2 CRISPRa kit - CRISPR gene activation of human apolipoprotein C2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: APOC2
• Locus ID: 344
• Kit Components:

  GA100243G1, Apolipoprotein CII gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100243G2, Apolipoprotein CII gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100243G3, Apolipoprotein CII gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000483
• Synonyms: APO-CII; APOC-II
• Summary: 'This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]'