Human Prostate Specific Antigen (KLK3) activation kit by CRISPRa

CAT#: GA100251

KLK3 CRISPRa kit - CRISPR gene activation of human kallikrein related peptidase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLK3
• Locus ID: 354
• Kit Components:

  GA100251G1, Prostate Specific Antigen gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100251G2, Prostate Specific Antigen gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100251G3, Prostate Specific Antigen gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001030047, NM_001030048, NM_001030049, NM_001030050, NM_001648, NM_145864
• Synonyms: APS; hK3; KLK2A1; PSA
• Summary: 'Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]'