Human Aquaporin 3 (AQP3) activation kit by CRISPRa

CAT#: GA100257

AQP3 CRISPRa kit - CRISPR gene activation of human aquaporin 3 (Gill blood group)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AQP3
• Locus ID: 360
• Kit Components:

  GA100257G1, Aquaporin 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100257G2, Aquaporin 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100257G3, Aquaporin 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318144, NM_004925
• Synonyms: AQP-3; GIL
• Summary: This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]