Human Aquaporin 4 (AQP4) activation kit by CRISPRa

CAT#: GA100258

AQP4 CRISPRa kit - CRISPR gene activation of human aquaporin 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AQP4
• Locus ID: 361
• Kit Components:

  GA100258G1, Aquaporin 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100258G2, Aquaporin 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100258G3, Aquaporin 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317384, NM_001317387, NM_001650, NM_004028, N50070, NM_001364286, NM_001364289, NM_001364287
• Synonyms: HMIWC2; MIWC
• Summary: 'This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Additional isoforms, resulting from the use of alternative in-frame translation initiation codons, have also been described. Recent studies provided evidence for translational readthrough in this gene, and expression of C-terminally extended isoforms via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]'