Human Arginase 1 (ARG1) activation kit by CRISPRa

CAT#: GA100275

ARG1 CRISPRa kit - CRISPR gene activation of human arginase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARG1
• Locus ID: 383
• Kit Components:

  GA100275G1, Arginase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100275G2, Arginase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100275G3, Arginase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000045, NM_001244438, NR_160934, NM_001369020
• Synonyms: arginase, liver; arginase 1; liver-type arginase; OTTHUMP00000017209; type I arginase
• Summary: 'Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]'