Human ARHGAP4 activation kit by CRISPRa

CAT#: GA100283

ARHGAP4 CRISPRa kit - CRISPR gene activation of human Rho GTPase activating protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGAP4
• Locus ID: 393
• Kit Components:

  GA100283G1, ARHGAP4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100283G2, ARHGAP4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100283G3, ARHGAP4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164741, NM_001666
• Synonyms: C1; p115; RGC1; RhoGAP4; SrGAP4
• Summary: 'This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]'