Human RhoGDI (ARHGDIA) activation kit by CRISPRa

CAT#: GA100286

ARHGDIA CRISPRa kit - CRISPR gene activation of human Rho GDP dissociation inhibitor alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGDIA
• Locus ID: 396
• Kit Components:

  GA100286G1, RhoGDI gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100286G2, RhoGDI gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100286G3, RhoGDI gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001185077, NM_001185078, NM_001301240, NM_001301241, NM_001301242, NM_001301243, NM_004309, NR_125441, NM_001301240.2, NM_001301241.2, NM_001301243.2, NM_001301242.2
• Synonyms: GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1
• Summary: 'This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]'