Human Asialoglycoprotein Receptor 2 (ASGR2) activation kit by CRISPRa

CAT#: GA100313

ASGR2 CRISPRa kit - CRISPR gene activation of human asialoglycoprotein receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ASGR2
• Locus ID: 433
• Kit Components:

  GA100313G1, Asialoglycoprotein Receptor 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100313G2, Asialoglycoprotein Receptor 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100313G3, Asialoglycoprotein Receptor 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001181, NM_001201352, NM_080912, NM_080913, NM_080914
• Synonyms: ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2
• Summary: 'This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]'