Human Antithrombin III (SERPINC1) activation kit by CRISPRa

CAT#: GA100323

SERPINC1 CRISPRa kit - CRISPR gene activation of human serpin family C member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SERPINC1
• Locus ID: 462
• Kit Components:

  GA100323G1, Antithrombin III gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100323G2, Antithrombin III gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100323G3, Antithrombin III gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000488, NM_001365052
• Synonyms: AT3; AT3D; ATIII; THPH7
• Summary: 'The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]'