Human ATOX1 activation kit by CRISPRa

CAT#: GA100332

ATOX1 CRISPRa kit - CRISPR gene activation of human antioxidant 1 copper chaperone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATOX1
• Locus ID: 475
• Kit Components:

  GA100332G1, ATOX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100332G2, ATOX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100332G3, ATOX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004045
• Synonyms: ATX1; HAH1
• Summary: 'This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]'