Human Sodium Potassium ATPase (ATP1A1) activation kit by CRISPRa

CAT#: GA100333

ATP1A1 CRISPRa kit - CRISPR gene activation of human ATPase Na+/K+ transporting subunit alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP1A1
• Locus ID: 476
• Kit Components:

  GA100333G1, Sodium Potassium ATPase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100333G2, Sodium Potassium ATPase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100333G3, Sodium Potassium ATPase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000701, NM_001001586, NM_001160233, NM_001160234
• Synonyms: MGC3285; MGC51750
• Summary: 'The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]'