Human ALDH7A1 activation kit by CRISPRa

CAT#: GA100352

ALDH7A1 CRISPRa kit - CRISPR gene activation of human aldehyde dehydrogenase 7 family member A1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALDH7A1
• Locus ID: 501
• Kit Components:

  GA100352G1, ALDH7A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100352G2, ALDH7A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100352G3, ALDH7A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001182, NM_001201377, NM_001202404
• Synonyms: ATQ1; EPD; PDE
• Summary: 'The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]'