Human ATP6V0C activation kit by CRISPRa

CAT#: GA100366

ATP6V0C CRISPRa kit - CRISPR gene activation of human ATPase H+ transporting V0 subunit c

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP6V0C
• Locus ID: 527
• Kit Components:

  GA100366G1, ATP6V0C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100366G2, ATP6V0C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100366G3, ATP6V0C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198569, NM_001694
• Synonyms: ATP6C; ATP6L; ATPL; VATL; Vma3; VPPC
• Summary: 'This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]'