Human ATP7A activation kit by CRISPRa

CAT#: GA100373

ATP7A CRISPRa kit - CRISPR gene activation of human ATPase copper transporting alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP7A
• Locus ID: 538
• Kit Components:

  GA100373G1, ATP7A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100373G2, ATP7A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100373G3, ATP7A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000052, NM_001282224, NR_104109
• Synonyms: DSMAX; MK; MNK; SMAX3
• Summary: 'This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013]'