Human ATP7B activation kit by CRISPRa

CAT#: GA100375

ATP7B CRISPRa kit - CRISPR gene activation of human ATPase copper transporting beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP7B
• Locus ID: 540
• Kit Components:

  GA100375G1, ATP7B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100375G2, ATP7B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100375G3, ATP7B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000053, NM_001005918, NM_001243182, NM_001330578, NM_001330579
• Synonyms: PWD; WC1; WD; WND
• Summary: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008]