Human ATR activation kit by CRISPRa

CAT#: GA100376

ATR CRISPRa kit - CRISPR gene activation of human ATR serine/threonine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATR
• Locus ID: 545
• Kit Components:

  GA100376G1, ATR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100376G2, ATR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100376G3, ATR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184, NM_001354579
• Synonyms: FCTCS; FRP1; MEC1; SCKL; SCKL1
• Summary: 'The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]'