Human BACH1 activation kit by CRISPRa

CAT#: GA100390

BACH1 CRISPRa kit - CRISPR gene activation of human BTB domain and CNC homolog 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BACH1
• Locus ID: 571
• Kit Components:

  GA100390G1, BACH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100390G2, BACH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100390G3, BACH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001011545, NM_001186, NM_206866, NR_027655
• Synonyms: BACH-1; BTB and CNC homology 1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; OTTHUMP00000096564
• Summary: 'This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]'