Human BAG1 activation kit by CRISPRa

CAT#: GA100392

BAG1 CRISPRa kit - CRISPR gene activation of human BCL2 associated athanogene 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BAG1
• Locus ID: 573
• Kit Components:

  GA100392G1, BAG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100392G2, BAG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100392G3, BAG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172415, NM_004323, NM_001349286, NM_001349299
• Synonyms: HAP; RAP46
• Summary: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]