Human Bak (BAK1) activation kit by CRISPRa

CAT#: GA100397

BAK1 CRISPRa kit - CRISPR gene activation of human BCL2 antagonist/killer 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BAK1
• Locus ID: 578
• Kit Components:

  GA100397G1, Bak gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100397G2, Bak gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100397G3, Bak gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001188
• Synonyms: BAK; BAK-LIKE; BCL2L7; CDN1
• Summary: 'The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]'