Human BCL2L2 activation kit by CRISPRa

CAT#: GA100413

BCL2L2 CRISPRa kit - CRISPR gene activation of human BCL2 like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCL2L2
• Locus ID: 599
• Kit Components:

  GA100413G1, BCL2L2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100413G2, BCL2L2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100413G3, BCL2L2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199839, NM_004050
• Synonyms: BCL-W; BCL2-L-2; BCLW; PPP1R51
• Summary: 'This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]'