Human bcl 6 (BCL6) activation kit by CRISPRa

CAT#: GA100415

BCL6 CRISPRa kit - CRISPR gene activation of human BCL6 transcription repressor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCL6
• Locus ID: 604
• Kit Components:

  GA100415G1, bcl 6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100415G2, bcl 6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100415G3, bcl 6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130845, NM_001134738, NM_001706, NM_138931
• Synonyms: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
• Summary: 'The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]'