Human Bcl 7A (BCL7A) activation kit by CRISPRa

CAT#: GA100416

BCL7A CRISPRa kit - CRISPR gene activation of human BAF chromatin remodeling complex subunit BCL7A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCL7A
• Locus ID: 605
• Kit Components:

  GA100416G1, Bcl 7A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100416G2, Bcl 7A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100416G3, Bcl 7A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024808, NM_020993
• Synonyms: BCL7
• Summary: This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]