Human BDKRB1 activation kit by CRISPRa

CAT#: GA100424

BDKRB1 CRISPRa kit - CRISPR gene activation of human bradykinin receptor B1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BDKRB1
• Locus ID: 623
• Kit Components:

  GA100424G1, BDKRB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100424G2, BDKRB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100424G3, BDKRB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000710
• Synonyms: B1BKR; B1R; BDKRB2; BKB1R; BKR1; BRADYB1
• Summary: 'Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]'