Human BDKRB2 activation kit by CRISPRa

CAT#: GA100425

BDKRB2 CRISPRa kit - CRISPR gene activation of human bradykinin receptor B2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BDKRB2
• Locus ID: 624
• Kit Components:

  GA100425G1, BDKRB2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100425G2, BDKRB2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100425G3, BDKRB2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000623
• Synonyms: B2R; BK-2; BK2; BKR2; BRB2
• Summary: 'This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]'