Human BDNF activation kit by CRISPRa

CAT#: GA100426

BDNF CRISPRa kit - CRISPR gene activation of human brain derived neurotrophic factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BDNF
• Locus ID: 627
• Kit Components:

  GA100426G1, BDNF gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100426G2, BDNF gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100426G3, BDNF gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001143805, NM_001143806, NM_001143807, NM_001143808, NM_001143809, NM_001143810, NM_001143811, NM_001143812, NM_001143813, NM_001143814, NM_001143815, NM_001143816, NM_001709, NM_170731, NM_170732, NM_170733, NM_170734, NM_170735
• Synonyms: ANON2; BULN2
• Summary: 'This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]'