Human Osteocalcin (BGLAP) activation kit by CRISPRa

CAT#: GA100429

BGLAP CRISPRa kit - CRISPR gene activation of human bone gamma-carboxyglutamate protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BGLAP
• Locus ID: 632
• Kit Components:

  GA100429G1, Osteocalcin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100429G2, Osteocalcin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100429G3, Osteocalcin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000711, NM_199173
• Synonyms: BGP; bone gamma-carboxyglutamate (gla) protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone Gla protein; gamma-carboxyglutamic acid-containing protein; OC; Osteocalcin; OTTHUMP00000016586; PMF1
• Summary: 'This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]'