Human BMP3 activation kit by CRISPRa

CAT#: GA100447

BMP3 CRISPRa kit - CRISPR gene activation of human bone morphogenetic protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BMP3
• Locus ID: 651
• Kit Components:

  GA100447G1, BMP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100447G2, BMP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100447G3, BMP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001201
• Synonyms: BMP-3A
• Summary: 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016]'