Human BTK activation kit by CRISPRa

CAT#: GA100484

BTK CRISPRa kit - CRISPR gene activation of human Bruton tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BTK
• Locus ID: 695
• Kit Components:

  GA100484G1, BTK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100484G2, BTK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100484G3, BTK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000061, NM_001287344, NM_001287345
• Synonyms: AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
• Summary: 'The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]'