Human BubR1 (BUB1B) activation kit by CRISPRa

CAT#: GA100487

BUB1B CRISPRa kit - CRISPR gene activation of human BUB1 mitotic checkpoint serine/threonine kinase B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BUB1B
• Locus ID: 701
• Kit Components:

  GA100487G1, BubR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100487G2, BubR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100487G3, BubR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001211
• Synonyms: Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1
• Summary: 'This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]'