Human C1QA activation kit by CRISPRa

CAT#: GA100492

C1QA CRISPRa kit - CRISPR gene activation of human complement C1q A chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: C1QA
• Locus ID: 712
• Kit Components:

  GA100492G1, C1QA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100492G2, C1QA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100492G3, C1QA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015991, NM_001347465, NM_001347466
• Synonyms: complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain; OTTHUMP00000002936
• Summary: 'This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]'