Human Carbonic Anhydrase III (CA3) activation kit by CRISPRa

CAT#: GA100529

CA3 CRISPRa kit - CRISPR gene activation of human carbonic anhydrase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CA3
• Locus ID: 761
• Kit Components:

  GA100529G1, Carbonic Anhydrase III gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100529G2, Carbonic Anhydrase III gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100529G3, Carbonic Anhydrase III gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005181
• Synonyms: CAIII; Car3
• Summary: 'Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]'