Human CACNA1E activation kit by CRISPRa

CAT#: GA100542

CACNA1E CRISPRa kit - CRISPR gene activation of human calcium voltage-gated channel subunit alpha1 E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CACNA1E
• Locus ID: 777
• Kit Components:

  GA100542G1, CACNA1E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100542G2, CACNA1E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100542G3, CACNA1E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000721, NM_001205293, NM_001205294
• Synonyms: BII; CACH6; CACNL1A6; Cav2.3; gm139
• Summary: 'Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]'