Human CACNB4 activation kit by CRISPRa

CAT#: GA100550

CACNB4 CRISPRa kit - CRISPR gene activation of human calcium voltage-gated channel auxiliary subunit beta 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CACNB4
• Locus ID: 785
• Kit Components:

  GA100550G1, CACNB4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100550G2, CACNB4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100550G3, CACNB4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000726, NM_001005746, NM_001005747, NM_001145798, NM_001320722, NM_001330113, NM_001330114, NM_001330115, NM_001330116, NM_001330117, NM_001330118
• Synonyms: CAB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6
• Summary: 'This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5. [provided by RefSeq, Aug 2016]'