Human CAMK2A activation kit by CRISPRa

CAT#: GA100568

CAMK2A CRISPRa kit - CRISPR gene activation of human calcium/calmodulin dependent protein kinase II alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CAMK2A
• Locus ID: 815
• Kit Components:

  GA100568G1, CAMK2A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100568G2, CAMK2A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100568G3, CAMK2A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015981, NM_171825, NM_001363989, NM_001363990, NM_001369025
• Synonyms: CAMKA
• Summary: 'The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]'