Human Caspase 1 (CASP1) activation kit by CRISPRa

CAT#: GA100587

CASP1 CRISPRa kit - CRISPR gene activation of human caspase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP1
• Locus ID: 834
• Kit Components:

  GA100587G1, Caspase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100587G2, Caspase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100587G3, Caspase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001223, NM_001257118, NM_001257119, NM_033292, NM_033293, NM_033294, NM_033295
• Synonyms: ICE; IL1BC; P45
• Summary: 'This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]'