Human Caspase 5 (CASP5) activation kit by CRISPRa

CAT#: GA100591

CASP5 CRISPRa kit - CRISPR gene activation of human caspase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP5
• Locus ID: 838
• Kit Components:

  GA100591G1, Caspase 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100591G2, Caspase 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100591G3, Caspase 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136109, NM_001136110, NM_001136111, NM_001136112, NM_004347, NR_024239, NR_036562
• Synonyms: ICE(rel)III; ICEREL-III; ICH-3
• Summary: 'This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]'