Human Caspase 10 (CASP10) activation kit by CRISPRa

CAT#: GA100596

CASP10 CRISPRa kit - CRISPR gene activation of human caspase 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP10
• Locus ID: 843
• Kit Components:

  GA100596G1, Caspase 10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100596G2, Caspase 10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100596G3, Caspase 10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206524, NM_001206542, NM_001230, NM_001306083, NM_032974, NM_032976, NM_032977
• Synonyms: ALPS2; FLICE2; MCH4
• Summary: 'This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]'