Human Calcium Sensing Receptor (CASR) activation kit by CRISPRa

CAT#: GA100599

CASR CRISPRa kit - CRISPR gene activation of human calcium sensing receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASR
• Locus ID: 846
• Kit Components:

  GA100599G1, Calcium Sensing Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100599G2, Calcium Sensing Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100599G3, Calcium Sensing Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000388, NM_001178065
• Synonyms: CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1
• Summary: 'The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]'