Human Caveolin 1 (CAV1) activation kit by CRISPRa

CAT#: GA100601

CAV1 CRISPRa kit - CRISPR gene activation of human caveolin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CAV1
• Locus ID: 857
• Kit Components:

  GA100601G1, Caveolin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100601G2, Caveolin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100601G3, Caveolin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172895, NM_001172896, NM_001172897, NM_001753
• Synonyms: BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21
• Summary: 'The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]'