Human RUNX1 activation kit by CRISPRa

CAT#: GA100605

RUNX1 CRISPRa kit - CRISPR gene activation of human RUNX family transcription factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RUNX1
• Locus ID: 861
• Kit Components:

  GA100605G1, RUNX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100605G2, RUNX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100605G3, RUNX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001890, NM_001122607, NM_001754
• Synonyms: AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB
• Summary: 'Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'