Human RUNX1T1 activation kit by CRISPRa

CAT#: GA100606

RUNX1T1 CRISPRa kit - CRISPR gene activation of human RUNX1 partner transcriptional co-repressor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RUNX1T1
• Locus ID: 862
• Kit Components:

  GA100606G1, RUNX1T1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100606G2, RUNX1T1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100606G3, RUNX1T1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198625, NM_001198626, NM_001198627, NM_001198628, NM_001198629, NM_001198630, NM_001198631, NM_001198632, NM_001198633, NM_001198634, NM_001198679, NM_004349, NM_175634, NM_175635, NM_175636
• Synonyms: AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
• Summary: 'This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]'