Human RUNX3 activation kit by CRISPRa

CAT#: GA100608

RUNX3 CRISPRa kit - CRISPR gene activation of human RUNX family transcription factor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RUNX3
• Locus ID: 864
• Kit Components:

  GA100608G1, RUNX3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100608G2, RUNX3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100608G3, RUNX3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001031680, NM_001320672, NM_004350
• Synonyms: AML2; CBFA3; PEBP2aC
• Summary: 'This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]'