Human CD4 activation kit by CRISPRa

CAT#: GA100647

CD4 CRISPRa kit - CRISPR gene activation of human CD4 molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CD4
• Locus ID: 920
• Kit Components:

  GA100647G1, CD4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100647G2, CD4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100647G3, CD4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000616, NM_001195014, NM_001195015, NM_001195016, NM_001195017, NR_036545
• Synonyms: CD4mut
• Summary: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]