Human CD14 activation kit by CRISPRa

CAT#: GA100656

CD14 CRISPRa kit - CRISPR gene activation of human CD14 molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CD14
• Locus ID: 929
• Kit Components:

  GA100656G1, CD14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100656G2, CD14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100656G3, CD14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000591, NM_001040021, NM_001174104, NM_001174105
• Synonyms: CD14 antigen; CD14 molecule; monocyte differentiation antigen CD14
• Summary: 'The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]'